The top seeded pair was shocked by Americans Andy Roddick and Mardy Fish in the first round of the Indianapolis Tennis Championships.
World number two Rafael Nadal led an exodus of seeds at Queen's Club on Friday when swirling winds threw Wimbledon preparations off course for several players.
Just 24 hours after showing second seed Andy Roddick the exit, the French wildcard ended Hewitt's challenge at the Poertschach International.
Czech Tomas Berdych halted fifth seed Juan Martin Del Potro's hot streak by beating the Argentine 6-1, 6-4 to win the Japan Open on Sunday. Ninth seed Berdych's fourth ATP Tour title and his first since winning on grass in Halle last year came after Del Potro left the court to take medicine for an upset stomach.
Argentine Juan Martin Del Potro ended top seed David Ferrer's reign as Japan Open champion with a 6-1, 7-5 quarter-final victory.
Top seed David Ferrer of Spain was bundled out of the $524,000 China Open by Israel's Dudi Sela on Thursday, while big-serving American Andy Roddick swept past compatriot Brendan Evans to book a quarter-final place.
Novak Djokovic said he overreacted to jokes about his long list of injuries when he lashed out at Andy Roddick after defeating the American on Thursday to reach the semi-finals of the US Open. Roddick had commented to the crowd courtside after his previous match on the assorted maladies cited by Djokovic, who complained about stomach, hip, ankle and breathing problems during his five-set win against Spain's Tommy Robredo.
Serena Williams stayed on course for a fourth Sony Ericsson Open title with a ruthless 6-1 6-4 win over Czech Nicole Vaidisova in the quarter-finals on Wednesday.
Russian Igor Kunitsyn ended the run of Indian qualifier Somdev Devvarman with a 6-4, 6-1 victory in the quarter-finals of the Washington ATP.
He strongly criticised Wimbledon organisers after his fellow Australian Lleyton Hewitt was seeded three.
The fourth seeded Indo-Bahamas pair got a walkover from the American duo of Mardy Fish and Andy Roddick in the second round of the ATP Rogers Masters.
The Swiss world number one needed more than 2- hours to squeeze past Czech Radek Stepanek in Melbourne.
Rafael Nadal ended Andy Roddick's bid for a record fifth title at Queen's by charging into the final with a 7-5, 6-4 win.
Roger Federer beat Ivan Ljubicic 7-6, 6-4 to bring David Nalbandian through with him.
Tennis ace Andy Roddick's luscious blonde wife Brooklyn Decker says she is too curvy to be a runway model.
World number two Andy Roddick will take on in-form Russian Marat Safin in the season-ending ATP Tennis Masters Cup.
James Blake joined compatriots Andy Roddick and Robby Ginepri in the last four of the RCA Championships.
James Blake ended the three-year Queen's Club reign of Andy Roddick to announce himself as a surprise contender for Wimbledon.
Sebastian Korda is just the third American to reach the quarter-finals at the Australian Open.
James Blake beat Russian Mikhail Youzhny in the second singles after American No 1 Andy Roddick outclassed Dmitry Tursunov in the opening rubber.
Wimbledon picks up the pace dramatically today with the fourth round of the men's and women's singles.
The Swiss will play Nadal's countryman David Ferrer in Sunday's final at the showcase eight-man event in Shanghai following his 6-1, 6-3 thrashing of American Andy Roddick in the first semi-final.
The Swiss beat Nikolay Davydenko 6-4, 6-3 to stay alive in the Tennis Masters Cup in Shanghai, while American Andy Roddick became the first player to book a semi-final spot at the season-ending event in Shanghai after crushing Chile's Fernando Gonzalez 6-1, 6-4.
The United States will take on Chile in the Davis Cup quarter-final on grass courts.
The Memorial Coliseum in Portland, Oregon, will host the November 30 - December 2 match.
The United States won 4-1 and will host defending champions Russia in the final.
World number one Roger Federer faces a lofty challenge in his bid for a fourth straight U.S. Open title when he takes on American wildcard John Isner in the third round on Saturday.
The world number one was beaten 3-6, 6-4, 6-4 by Germany's Tommy Haas at the invitational Kooyong Classic.
Martina Hingis was nearly caught napping on a gloomy day before she woke up in the nick of time to reach the second round.
The unseeded Russian beat Marcos Baghdatis to reach the quarter-finals of a Grand Slam for the first time at the French Open.
The Argentine concluded an ideal warm-up for the French Open with a 7-6, 6-0 win over the Frenchman in the Poertschach International final.
Roger Federer slumped to a 6-2, 6-4 defeat against Italian wild card Filippo Volandri in the last 16.
The big-serving Aussie beat Sebastien Grosjean in the first men's semi-final at Wimbledon.